SEATTLE, May 18, 2022 /PRNewswire/ — Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies in oncology, announced today its participation at Preclinical Immuno-oncology Online 2022. Thierry Guillaudeux, PhD, EVP Research and Development at Kineta, will make a presentation on "Human Knock-In Mice For Selecting Next Generation Immune Checkpoint Inhibitors" and participate in a panel discussion on "The Future of In Vivo Models" at the virtual symposium to be held on May 18, 2022.
As part of his presentation, Dr Guillaudeux will discuss key technology and advantages of Kineta’s proprietary PiiONEER™ platform. The company’s immuno-oncology platform was designed for the discovery and development of first or best-in-class immunotherapies that address the major challenges with cancer resistance to current therapies. Kineta has developed novel, innate immuno-oncology antibody therapeutics targeting VISTA and CD27.
"I am thrilled to participate in this symposium and discuss Kineta’s immuno-oncology focused PiiONEER™ platform," said Dr. Guillaudeux. "Kineta’s specialized in vivo preclinical models are used to characterize a therapeutic antibody’s anti-cancer efficacy, pharmacokinetics, receptor occupancy and biomarkers and are key development technologies in our innovative platform."
Kineta has developed monoclonal antibody programs targeting VISTA and CD27 through the PiiONEER™ platform. KVA12.1 is a potential best-in-class VISTA blocking immunotherapy. It is a fully human engineered IgG1 monoclonal antibody that was designed to bind to VISTA through a unique epitope. In preclinical models, KVA12.1 demonstrates strong single agent efficacy in cold tumors and complementary efficacy when dosed in combination with other checkpoint inhibitors (CPI’s). It is well-tolerated with no change IL6 and TNFα levels responsible for cytokine release syndrome (CRS) in preclinical toxicology studies. KVA12.1 is being developed as an intravenous infusion for patients with advanced solid tumors. Kineta plans to initiate Phase 1 clinical studies in Q4 2022. Kineta is also developing an anti-CD27 agonist monoclonal antibody for patients with solid and hematologic tumors. Kineta is in the final stage of lead selection and plans to nominate a clinical candidate in Q2 2022.
Preclinical Immuno-oncology Online 2022 is a virtual conference that assembles a wide range of senior leaders from leading healthcare, biotech, pharma and research institutions. The conference delves into the challenges and opportunities in innovative approaches to preclinical drug development with a goal to achieve translational success.
Title: The Future Of In Vivo Models
Presenter: Thierry Guillaudeux, PhD
Session Type: Panel discussion
Session Time: May 18, 2022 7:40AM – 8:10AM Pacific Time
Title: Human Knock-In Mice For Selecting Next Generation Immune Checkpoint Inhibitors
Presenter: Thierry Guillaudeux, PhD
Session Type: Virtual presentation
Session Time: May 18, 2022 8:30AM – 9:00AM Pacific Time
Kineta is a clinical stage biotechnology company with a mission to develop next generation immunotherapies that transform patients’ lives. We have leveraged our expertise in innate immunity to develop first or best-in-class immunotherapies that address the major challenges with current cancer therapy. For more information on Kineta visit our website, www.kinetabio.com, and follow us on Twitter, LinkedIn and Facebook.
NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta’s plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta’s business which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and Kineta undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.
SOURCE Kineta, Inc.